Compensatory hemagglutinin mutations alter antigenic 1 properties of influenza viruses
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چکیده
properties of influenza viruses 2 Jaclyn L. Myers, Katherine S. Wetzel, Susanne L. Linderman, Yang Li, Colleen 3 B. Sullivan, Scott E. Hensley 4 5 Wistar Institute, Philadelphia, PA 19104, USA 6 Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA 7 Institute for Immunology, University of Pennsylvania, Philadelphia, PA 19104, USA 8 These authors contributed equally 9 10 11 Short Title: Compensatory influenza HA mutations alter antigenicity 12 Abstract word count: 210 13 Text word count: 3380 14 15 16 17 18 19 20 21 22 23 24 #Correspondence to: 25 Scott E. Hensley, Ph.D. 26 The Wistar Institute 27 3601 Spruce St. Room 276 28 Philadelphia, PA 19104 29 [email protected] 30 P (215) 495-6864 31 F (215) 898-0709 32 Copyright © 2013, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.01414-13 JVI Accepts, published online ahead of print on 7 August 2013
منابع مشابه
Compensatory hemagglutinin mutations alter antigenic properties of influenza viruses.
Influenza viruses routinely acquire mutations in antigenic sites on the globular head of the hemagglutinin (HA) protein. Since these antigenic sites are near the receptor binding pocket of HA, many antigenic mutations simultaneously alter the receptor binding properties of HA. We previously reported that a K165E mutation in the Sa antigenic site of A/Puerto Rico/8/34 (PR8) HA is associated with...
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تاریخ انتشار 2013